Search on: CALCIUM RELEASE ACTIVATED CHANNELS 
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Descriptor English:   Calcium Release Activated Calcium Channels 
Descriptor Spanish:   Canales de Calcio Activados por la Liberación de Calcio 
Descriptor Portuguese:   Canais de Cálcio Ativados pela Liberação de Cálcio 
Synonyms English:   CRAC Channels
Calcium Release-Activated Calcium Channels
Calcium Release-Activated Channels
Calcium Release Activated Channels  
Tree Number:   D12.776.157.530.400.150.740
D12.776.543.550.450.150.740
D12.776.543.585.400.150.740
Definition English:   Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56582 
Unique Identifier:   D000071739 

Occurrence in VHL:
 

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